A Recombinant Protein SARS-CoV-2 Candidate Vaccine Elicits High-titer Neutralizing Antibodies in Macaques.

ABSTRACT:

Background

Vaccines that generate robust and long-lived protective immunity against SARS-CoV-2 infection are urgently required.

Methods

We assessed the potential of vaccine candidates based on the SARS-CoV-2 spike in cynomolgus macaques (M. fascicularis) by examining their ability to generate spike binding antibodies with neutralizing activity. Antigens were derived from two distinct regions of the spike S1 subunit, either the N-terminal domain or an extended C-terminal domain containing the receptor-binding domain and were fused to the human IgG1 Fc domain. Three groups of 2 animals each were immunized with either antigen, alone or in combination. The development of antibody responses was evaluated through 20 weeks post-immunization.

Results

A robust IgG respo

SUBMITTER: Baisa G 

PROVIDER: S-EPMC7805460 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature