COVID-19-Associated Nonocclusive Fibrin Microthrombi in the Heart.

ABSTRACT:

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant clinical presentation, coronavirus disease 2019 (COVID-19), is an emergent cause of mortality worldwide. Cardiac complications secondary to this infection are common; however, the underlying mechanisms of such remain unclear. A detailed cardiac evaluation of a series of individuals with COVID-19 undergoing postmortem evaluation is provided, with 4 aims: (1) describe the pathological spectrum of the myocardium; (2) compare with an alternate viral illness; (3) investigate angiotensin-converting enzyme 2 expression; and (4) provide the first description of the cardiac findings in patients with cleared infection.

Methods

Study cases were identified from institutional files and included COVI

SUBMITTER: Bois MC 

PROVIDER: S-EPMC7805556 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature