Oral Corticosteroids and Risk of Preterm Birth in the California Medicaid Program.

ABSTRACT:

Background

There is limited information regarding the impact of dose and gestational timing of oral corticosteroid (OCS) use on preterm birth (PTB), especially among women with asthma.

Objectives

To evaluate OCS dose and timing on PTB for asthma and, as a comparison, systemic lupus erythematosus (SLE).

Methods

We used health care data from California Medicaid enrollees linked to birth certificates (2007-2013), identifying women with asthma (n = 22,084) and SLE (n = 1174). We estimated risk ratios (RR) for OCS cumulative dose trajectories and other disease-related medications before gestational day 140 and hazard ratios (HR) for time-varying exposures after day 139.

Results

For asthma, PTB risk was 14.0% for no OCS exposure and 14.3%, 16.8%, 20.5%, and 32.7% in

SUBMITTER: Palmsten K 

PROVIDER: S-EPMC7805577 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature