O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.

ABSTRACT: The dopamine system in the midbrain is essential for volitional movement, action selection, and reward-related learning. Despite its versatile roles, it contains only a small set of neurons in the brainstem. These dopamine neurons are especially susceptible to Parkinson's disease and prematurely degenerate in the course of disease progression, while the discovery of new therapeutic interventions has been disappointingly unsuccessful. Here, we show that O-GlcNAcylation, an essential post-translational modification in various types of cells, is critical for the physiological function and survival of dopamine neurons. Bidirectional modulation of O-GlcNAcylation importantly regulates dopamine neurons at the molecular, synaptic, cellular, and behavioural levels. Remarkably, genetic and pharmaco

SUBMITTER: Lee BE 

PROVIDER: S-EPMC7805798 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature