Disentangling vulnerability, state and trait features of neurocognitive impairments in depression.

ABSTRACT: Depression is a debilitating disorder that often starts manifesting in early childhood and peaks in onset during adolescence. Neurocognitive impairments have emerged as clinically important characteristics of depression, but it remains controversial which domains specifically index pre-existing vulnerability, state-related or trait-related markers. Here, we disentangled these effects by analysing the Adolescent Brain Cognitive Development dataset (n = 4626). Using information of participants' current and past mental disorders, as well as family mental health history, we identified low-risk healthy (n = 2100), high-risk healthy (n = 2023), remitted depressed (n = 401) and currently depressed children (n = 102). Factor analysis of 11 cognitive variables was performed to elucidate latent stru

SUBMITTER: Ang YS 

PROVIDER: S-EPMC7805803 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature