Characteristics and etiologies of hepatocellular carcinoma in patients without cirrhosis: When East meets West.

ABSTRACT:

Background/aims

A recent study from the United States reported that nearly 12% of hepatocellular carcinomas (HCCs) occurred in patients without cirrhosis. Non-alcoholic fatty liver disease (NAFLD) was the most common liver disease in these patients. We aim to evaluate the characteristics, etiologies, and outcomes of cases of non-cirrhotic HCC in East Asia, where there is a higher prevalence of hepatitis B virus (HBV)-associated non-cirrhotic HCC.

Methods

This retrospective study consecutively enrolled de novo HCC patients managed at our institution from 2011 to 2017. The presence of cirrhosis was assessed by histology; if histology was not available, it was assessed by image study.

Results

2055 patients with HCC were enrolled in this study. Among them, 529 (25.7%) wer

SUBMITTER: Yen YH 

PROVIDER: S-EPMC7806135 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature