Ontology highlight
ABSTRACT:
SUBMITTER: Trizzino M
PROVIDER: S-EPMC7806227 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Science advances 20210113 3
Monocytes and monocyte-derived macrophages originate through a multistep differentiation process. First, hematopoietic stem cells generate lineage-restricted progenitors that eventually develop into peripheral, postmitotic monocytes. Second, blood-circulating monocytes undergo differentiation into macrophages, which are specialized phagocytic cells capable of tissue infiltration. While monocytes mediate some level of inflammation and cell toxicity, macrophages boast the widest set of defense mec ...[more]