Meta-Analysis Reveals the Prognostic Relevance of Nuclear and Membrane-Associated Bile Acid Receptors in Gastric Cancer.

ABSTRACT:

Introduction

Bile acids (BAs) arising from duodenogastric reflux are known to facilitate gastric cancer (GC) development. Although BAs traditionally contribute to carcinogenesis through direct cellular cytotoxicity, increasing evidence implicates nuclear and membrane BA receptors (BARs) as additional factors influencing cancer risk. Indeed, some BARs are already linked with GC, but conflicting evidence and lack of information regarding other endogenous BARs warrant further investigation. In this study, we meta-analyzed multiple data sets to identify clinically relevant relationships between BAR expression and prognosis, clinicopathology, and activity in GC.

Methods

We collected transcriptomic data from the Gene Expression Omnibus and The Cancer Genome Atlas to analyze associ

SUBMITTER: Rohr M 

PROVIDER: S-EPMC7806235 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature