IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer.

ABSTRACT: Rationale: Tumor microenvironment interacts with tumor cells to regulate their stemness properties through various cytokines and cytokine receptors. Previous studies revealed the possible role of interleukin 20 receptor subunit alpha (IL20RA) signaling in the progression of several types of tumors. However, its regulatory effects on the stemness and the microenvironment of breast cancer need to be studied. Methods: Immunohistochemical staining and western blot analysis were used to evaluate the association between IL20RA and SOX2 in breast tumors and noncancerous tissues. Enzyme-linked immunosorbent assay and TCGA dataset analysis were performed to determine the function of IL20RA signaling in breast cancer progression. Gain- and loss-of-function methods were performed to exa

SUBMITTER: Gao W 

PROVIDER: S-EPMC7806486 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature