Catalytic patch with redox Cr/CeO₂ nanozyme of noninvasive intervention for brain trauma.

ABSTRACT: Traumatic brain injury (TBI) is a sudden injury to the brain, accompanied by the production of large amounts of reactive oxygen and nitrogen species (RONS) and acute neuroinflammation responses. Although traditional pharmacotherapy can effectively decrease the immune response of neuron cells via scavenging free radicals, it always involves in short reaction time as well as rigorous clinical trial. Therefore, a noninvasive topical treatment method that effectively eliminates free radicals still needs further investigation. Methods: In this study, a type of catalytic patch based on nanozymes with the excellent multienzyme-like activity is designed for noninvasive treatment of TBI. The enzyme-like activity, free radical scavenging ability and therapeutic efficacy of the designed cataly

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7806487 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature