Remdesivir therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Purpose

To perform a systematic review and meta-analysis of randomized controlled trials that examined remdesivir treatment for COVID-19.

Materials and methods

A systematic literature search was performed using Pubmed, Embase, and ClinicalTrials.gov to identify studies published up to October 25, 2020 that examined COVID-19 treatment with remdesivir. A total of 3 randomized controlled trials that consisted of 1691 patients were included in the meta-analysis.

Results

The odds for mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO) following treatment was significantly lower in the remdesivir group compared to the control group (OR = 0.48 [95% CI: 0.34; 0.69], p < 0.001). The odds of early (at day 14/15; OR = 1.42 [95% CI: 1.16; 1.74], p<

SUBMITTER: Reddy Vegivinti CT 

PROVIDER: S-EPMC7806502 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature