Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.

ABSTRACT: Cytoglobin is important in the progression of oral squamous cell carcinoma but the molecular and cellular basis remain to be elucidated. In the current study, we develop a new cell model to study the function of cytoglobin in oral squamous carcinoma and response to cisplatin. Transcriptomic profiling showed cytoglobin mediated changes in expression of genes related to stress response, redox metabolism, mitochondrial function, cell adhesion, and fatty acid metabolism. Cellular and biochemical studies show that cytoglobin expression results in changes to phenotype associated with cancer progression including: increased cellular proliferation, motility and cell cycle progression. Cytoglobin also protects cells from cisplatin-induced apoptosis and oxidative stress with levels of the antioxidan

SUBMITTER: Thorne LS 

PROVIDER: S-EPMC7806642 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature