Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models.

ABSTRACT: Immune cells play critical functions in cancer, and mice with intact immune systems are vital to understanding tumor immunology. Both genetically engineered mouse models (GEMMs) and syngeneic cell transplant approaches use immunocompetent mice to define immune-dependent events in tumor development and progression. Due to their rapid and reproducible nature, there is expanded interest in developing new syngeneic tools from established primary tumor models. However, few studies have examined the extent that syngeneic tumors reflect the immune profile of their originating primary models. Here, we describe comprehensive immunophenotyping of two well-established GEMMs and four new syngeneic models derived from these parental primary tumors. To our knowledge, this is the first systematic analysi

SUBMITTER: Gutierrez WR 

PROVIDER: S-EPMC7806664 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature