Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus).

ABSTRACT: The ability to associate memorized objects with their location in space gradually declines during normal aging and can drastically be affected by neurodegenerative diseases. This study investigates object-location paired-associates learning (PAL) in the grey mouse lemur (Microcebus murinus), a nonhuman primate model of brain aging. Touchscreen-based testing of 6 young adults (1-5 years) and 6 old adults (> 7 years) in the procedural rodent dPAL-task revealed significant age-related performance decline, evident in group differences in the percentage of correct decision during learning and the number of sessions needed to reach a predefined criterion. Response pattern analyses suggest decreased susceptibility to relative stimulus-position biases in young animals, facilitating PAL. Additional

SUBMITTER: Schmidtke D 

PROVIDER: S-EPMC7806666 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature