Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population.

ABSTRACT: After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. The Guarani-Kaiowá people are an indigenous population in Paraguay and the Brazilian state of Mato Grosso do Sul. This community, marginalized in Brazilian society, experiences severe poverty. Like other South American indigenous populations, their TB prevalence is high, but the disease has remained largely unstudied in their communities. Herein, Mycobacterium tuberculosis isolates from local clinics were whole genome sequenced, and a population genetic framework was generated. Phylogenetics show M. tuberculosis isolates in the Guarani-Kaiowá p

SUBMITTER: Hadi SA 

PROVIDER: S-EPMC7806709 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature