Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa.

ABSTRACT: Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n = 20). In contrast, percentages of CD1d⁺CD5⁺ B cells and transitional B cells w

SUBMITTER: Freff J 

PROVIDER: S-EPMC7806719 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature