Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency.

ABSTRACT: Inborn errors of metabolism are often associated with neurodevelopmental disorders and brain injury. A deficiency of aminopeptidase P1, a proline-specific endopeptidase encoded by the Xpnpep1 gene, causes neurological complications in both humans and mice. In addition, aminopeptidase P1-deficient mice exhibit hippocampal neurodegeneration and impaired hippocampus-dependent learning and memory. However, the molecular and cellular changes associated with hippocampal pathology in aminopeptidase P1 deficiency are unclear. We show here that a deficiency of aminopeptidase P1 modifies the glial population and neuronal excitability in the hippocampus. Microarray and real-time quantitative reverse transcription-polymerase chain reaction analyses identified 14 differentially expressed genes (Casp1,

SUBMITTER: Yoon SH 

PROVIDER: S-EPMC7806765 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature