(¹³C)-Methacetin breath test provides evidence of subclinical liver dysfunction linked to fat storage but not lifestyle.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease (NAFLD) is characterised by the presence of hepatic steatosis in the absence of other causes of secondary hepatic fat accumulation, and is usually associated with visceral, metabolically active obesity. However, the subclinical effects of body and liver fat accumulation on liver function are still unclear.

Methods

We used orally administered (¹³C)-methacetin and breath test to quantify the efficiency of hepatic extraction from portal blood flow and liver microsomal function in 81 participants, in relation to presence/absence of ultrasonographic NAFLD, extent of body fat accumulation, insulin resistance, dietary models, and lifestyle.

Results

NAFLD was present in 23% of participants with normal weight, and

SUBMITTER: Molina-Molina E 

PROVIDER: S-EPMC7806794 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature