Fear-induced brain activations distinguish anxious and trauma-exposed brains.

ABSTRACT: Translational models of fear conditioning and extinction have elucidated a core neural network involved in the learning, consolidation, and expression of conditioned fear and its extinction. Anxious or trauma-exposed brains are characterized by dysregulated neural activations within regions of this fear network. In this study, we examined how the functional MRI activations of 10 brain regions commonly activated during fear conditioning and extinction might distinguish anxious or trauma-exposed brains from controls. To achieve this, activations during four phases of a fear conditioning and extinction paradigm in 304 participants with or without a psychiatric diagnosis were studied. By training convolutional neural networks (CNNs) using task-specific brain activations, we reliably distinguis

SUBMITTER: Wen Z 

PROVIDER: S-EPMC7806917 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature