Multiplex gene and phenotype network to characterize shared genetic pathways of epilepsy and autism.

ABSTRACT: It is well established that epilepsy and autism spectrum disorder (ASD) commonly co-occur; however, the underlying biological mechanisms of the co-occurence from their genetic susceptibility are not well understood. Our aim in this study is to characterize genetic modules of subgroups of epilepsy and autism genes that have similar phenotypic manifestations and biological functions. We first integrate a large number of expert-compiled and well-established epilepsy- and ASD-associated genes in a multiplex network, where one layer is connected through protein-protein interaction (PPI) and the other layer through gene-phenotype associations. We identify two modules in the multiplex network, which are significantly enriched in genes associated with both epilepsy and autism as well as genes high

SUBMITTER: Peng J 

PROVIDER: S-EPMC7806931 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature