Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection.

ABSTRACT: Inferences from genetic association studies rely largely on the definition and description of the underlying populations that highlight their genetic similarities and differences. The clustering of human populations into subgroups (population structure) can significantly confound disease associations. This study investigated the fine-scale genetic structure within Cameroon that may underlie disparities observed with Cameroonian ethnicities in malaria genome-wide association studies in sub-Saharan Africa. Genotype data of 1073 individuals from three regions and three ethnic groups in Cameroon were analyzed using measures of genetic proximity to ascertain fine-scale genetic structure. Model-based clustering revealed distinct ancestral proportions among the Bantu, Semi-Bantu and Foulbe ethnic

SUBMITTER: Esoh KK 

PROVIDER: S-EPMC7807043 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature