Clinicopathological and prognostic impact of somatic mutations in Chinese patients with clear cell renal cell carcinoma.

ABSTRACT:

Background

The study of the genomic landscape of Chinese clear cell renal cell carcinoma (ccRCC) entered its nascence in recent years, and the clinical relevance of individual genes in Chinese ccRCC has not yet been researched. The study aimed to explore the relationships between somatic mutations and clinical behaviors in Chinese ccRCC.

Methods

Tumor tissue samples were obtained from 105 Chinese patients with ccRCC and deep sequencing targeting 556 cancer genes was performed. Correlation analysis, receiver operator characteristic (ROC) analysis and survival analysis were carried out using SPSS software.

Results

A total of 41 genes were used to investigate the relationship between genes and clinical behaviors. We found that different clinical indices were mutually cor

SUBMITTER: Bi H 

PROVIDER: S-EPMC7807320 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature