A new risk stratification system of prostate cancer to identify high-risk biochemical recurrence patients.

ABSTRACT:

Background

Biochemical recurrence (BCR) is considered a decisive risk factor for clinical recurrence and the metastasis of prostate cancer (PCa). Therefore, we developed and validated a signature which could be used to accurately predict BCR risk and aid in the selection of PCa treatments.

Methods

A comprehensive genome-wide analysis of data concerning PCa from previous datasets of the Cancer Genome Atlas (TCGA) and the gene expression omnibus (GEO) was performed. Lasso and Cox regression analyses were performed to develop and validate a novel signature to help predict BCR risk. Moreover, a nomogram was constructed by combining the signature and clinical variables.

Results

A total of 977 patients were involved in the study. This consisted of patients from the TCGA (n=

SUBMITTER: Wu X 

PROVIDER: S-EPMC7807327 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature