Autophagy-related genes are potential diagnostic and prognostic biomarkers in prostate cancer.

ABSTRACT:

Background

Recently, autophagy was found related to several malignances.

Methods

To explore the diagnostic and prognostic values of autophagy in prostate cancer (PCa), we first identified differentially expressed autophagy-related genes (DEARGs) based on The Cancer Genome Atlas (TCGA) Prostate Adenocarcinoma (PRAD) dataset. Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were applied to perform gene functional annotation. Then, multivariate logistic regression analysis was applied to construct the risk index (RI). Receiver operating characteristic (ROC), calibration and decision curve analysis (DCA) curves were performed to identify the effectiveness of RI. Next, multivariate Cox regression analyses were performed to construc

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC7807329 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature