Wild primate microbiomes prevent weight gain in germ-free mice.

ABSTRACT:

Background

The gut microbiome harbors trillions of bacteria that play a major role in dietary nutrient extraction and host metabolism. Metabolic diseases such as obesity and diabetes are associated with shifts in microbiome composition and have been on the rise in Westernized or highly industrialized countries. At the same time, Westernized diets low in dietary fiber have been shown to cause loss of gut microbial diversity. However, the link between microbiome composition, loss of dietary fiber, and obesity has not been well defined.

Results

To study the interactions between gut microbiota, dietary fiber, and weight gain, we transplanted captive and wild douc gut microbiota into germ-free mice and then exposed them to either a high- or low-fiber diet. The group receiving cap

SUBMITTER: Sidiropoulos DN 

PROVIDER: S-EPMC7807445 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature