Identification of a prognostic gene signature of colon cancer using integrated bioinformatics analysis.

ABSTRACT:

Background

Colon cancer is a worldwide leading cause of cancer-related mortality, and the prognosis of colon cancer is still needed to be improved. This study aimed to construct a prognostic model for predicting the prognosis of colon cancer.

Methods

The gene expression profile data of colon cancer were obtained from the TCGA, GSE44861, and GSE44076 datasets. The WGCNA module genes and common differentially expressed genes (DEGs) were used to screen out the prognosis-associated DEGs, which were used to construct a prognostic model. The performance of the prognostic model was assessed and validated in the TCGA training and microarray validation sets (GSE38832 and GSE17538). At last, the model and prognosis-associated clinical factors were used for the construction of the nomo

SUBMITTER: Fang Z 

PROVIDER: S-EPMC7807455 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature