Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.

ABSTRACT:

Background

Intervertebral disc degeneration (IVDD) is a primary cause of degenerative disc diseases; however, the mechanisms underlying the degeneration remain unclear. The immunoinflammatory response plays an important role in IVDD progression. The inflammatory cytokine lymphotoxin-α (LTα), formerly known as TNFβ, is associated with various pathological conditions, while its role in the pathogenesis of IVDD remains elusive.

Methods

Real-time quantitative polymerase chain reaction (RT-qPCR), Western blotting (WB), and enzyme-linked immunosorbent assays were used to assess the levels of LTα in human nucleus pulposus (NP) tissues between degeneration and control groups. The plasma concentrations of LTα and C-reactive protein (CRP) were compared between healthy and IVDD patient

SUBMITTER: Guo Z 

PROVIDER: S-EPMC7807514 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature