Online adaptive dose restoration in intensity modulated proton therapy of lung cancer to account for inter-fractional density changes.

ABSTRACT:

Background and purpose

In proton therapy, inter-fractional density changes can severely compromise the effective delivery of the planned dose. Such dose distortion effects can be accounted for by treatment plan adaptation, that requires considerable automation for widespread implementation in clinics. In this study, the clinical benefit of an automatic online adaptive strategy called dose restoration (DR) was investigated. Our objective was to assess to what extent DR could replace the need for a comprehensive offline adaptive strategy.

Materials and methods

The fully automatic and robust DR workflow was evaluated in a cohort of 14 lung IMPT patients that had a planning-CT and two repeated 4D-CTs (rCT1,rCT2). Initial plans were generated using 4D-robust optimization (includi

SUBMITTER: Borderias Villarroel E 

PROVIDER: S-EPMC7807540 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature