The effect of density overrides on magnetic resonance-guided radiation therapy planning for lung cancer.

ABSTRACT:

Background and purpose

Inverse treatment planning for lung cancer can be challenging since density heterogeneities may appear inside the planning target volume (PTV). One method to improve the quality of intensity modulation is the override of low density tissues inside the PTV during plan optimization. For magnetic resonance-guided radiation therapy (MRgRT), where the influence of the magnetic field on secondary electrons is sensitive to the tissue density, the reliability of density overrides has not yet been proven. This work, therefore, gains a first insight into density override strategies for MRgRT.

Material and methods

Monte Carlo-based treatment plans for five lung cancer patients were generated based on free-breathing CTs and two density override strategies. Differe

SUBMITTER: Schrenk O 

PROVIDER: S-EPMC7807559 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature