A biological modelling based comparison of radiotherapy plan robustness using photons vs protons for focal prostate boosting.

ABSTRACT:

Background and purpose

Focal tumour boosting is currently explored in radiotherapy of prostate cancer to increase tumour control. In this study we applied dose response models for both tumour control and normal tissue complications to explore the benefit of proton therapy (PT) combined with focal tumour boosting, also when accounting for inter-fractional motion.

Materials and methods

CT scans of seven patients fused with MRI-based index volumes were used. Two volumetric modulated arc therapy (VMAT) plans were created for each patient; one with conventional dose (77 Gy) to the entire prostate, and one with an additional integrated boost (total dose of 95 Gy) to the index lesion. Two corresponding intensity modulated PT (IMPT) plans were created using two lateral opposing spot

SUBMITTER: Pedersen J 

PROVIDER: S-EPMC7807577 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature