Clinical implementation of low-dose total body irradiation using topotherapy technique.

ABSTRACT:

Background and purpose

The topotherapy technique was recently suggested as a robust alternative to helical radiation delivery for total body irradiation (TBI). It allows to deliver a discrete number of beams with fixed gantry. A Topotherapy-based low-dose TBI technique was optimized and clinically implemented.

Materials and methods

TBI delivery was split in two parts: the first treating from the head to half thigh and the second the remaining legs. An in-silico investigation aimed to optimize plan parameters was first carried out on four patients. For the upper plan, field width and pitch were fixed to 5 cm and 0.5: the combined impact of five modulation factor (MF) values and different field configurations (6/8/12 fields) was investigated. For the lower plan, two anterior/p

SUBMITTER: Broggi S 

PROVIDER: S-EPMC7807637 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature