Stereotactic body proton therapy for liver tumors: Dosimetric advantages and their radiobiological and clinical implications.

ABSTRACT:

Background and purpose

Photon Stereotactic Body Radiotherapy (SBRT) for primary and metastatic tumors of the liver is challenging for larger lesions. An in silico comparison of paired SBRT and Stereotactic Body Proton Therapy (SBPT) plans was performed to understand the potential advantages of SBPT as a function of tumor size and location.

Methods and materials

Theoretical tumor volumes with maximum diameter of 1-10 cm were contoured in the dome, right inferior, left medial, and central locations. SBRT and SBPT plans were generated to deliver 50 Gy in 5 fractions, max dose <135%. When organs-at-risk (OAR) constraints were exceeded, hypothetical plans (not clinically acceptable) were generated for comparison. Liver normal tissue complication probability (NTCP) models w

SUBMITTER: Arscott WT 

PROVIDER: S-EPMC7807648 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature