A systematic review and meta-analysis of radiotherapy planning studies comparing multi leaf collimator designs.

ABSTRACT:

Background and purpose

Several studies have investigated multi leaf collimator (MLC) leaf design. We performed a systematic review and meta-analysis of those studies to compare the impact of MLC leaf width used for different radiotherapy techniques.

Materials and methods

We decided to focus on 2.5, 3.0 and 5.0 mm leaf width MLCs as it appeared to be the most contentious area from literature. We adopted Cochrane and PRISMA guidelines and computed the association between MLC leaf width and conformity index (CI) across the selected studies as pooled mean difference (PMD) with 95% confidence interval.

Results

A total of 43 papers were selected from the literature search, of which ten compare MLC leaf width of 2.5 mm or 3.0 mm (MLC2.5 mm) versus 5.0 mm (MLC5 mm) in terms o

SUBMITTER: Luzzara M 

PROVIDER: S-EPMC7807674 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature