Amine-Functionalized Nanoporous Silica Monoliths for Heterogeneous Catalysis of the Knoevenagel Condensation in Flow.

ABSTRACT: Porous carrier materials functionalized with organocatalysts offer substantial advantages compared to homogeneous catalysts, e.g., easy separation of the catalyst, scalability, and an improved implementation in continuous operations. Here, we report the immobilization of (3-aminopropyl)trimethoxysilane (APTMS) onto self-prepared silica monoliths and its application as a heterogeneous catalyst in the Knoevenagel condensation between cyano ethylacetate and various aromatic aldehydes under continuous-flow conditions. The meso-macroporous silica monoliths (6-7 cm in length) were optimized to be used in flow taking advantage of their hierarchical meso- and macroporosity. The monoliths were cladded with a poly(ether ether ketone) (PEEK) tube by a refined procedure to guarantee tight connection b

SUBMITTER: Turke K 

PROVIDER: S-EPMC7807742 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature