Clonal evolution in diffuse large B-cell lymphoma with central nervous system recurrence.

ABSTRACT:

Background

The prognosis of patients with secondary central nervous system lymphoma (SCNSL) is poor and despite massive advances in understanding the mutational landscape of primary diffuse large B-cell lymphoma (DLBCL), the genetic comparison to SCNSL is still lacking. We therefore collected paired samples from six patients with DLBCL with available biopsies from a lymph node (LN) at primary diagnosis and the central nervous system (CNS) at recurrence.

Patients and methods

A targeted, massively parallel sequencing approach was used to analyze 216 genes recurrently mutated in DLBCL. Healthy tissue from each patient was also sequenced in order to exclude germline mutations. The results of the primary biopsies were compared with those of the CNS recurrences to depict the genet

SUBMITTER: Magnes T 

PROVIDER: S-EPMC7807834 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature