Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease.

ABSTRACT:

Background

Clinical laboratory (lab) tests are used in clinical practice to diagnose, treat, and monitor disease conditions. Test results are stored in electronic health records (EHRs), and a growing number of EHRs are linked to patient DNA, offering unprecedented opportunities to query relationships between genetic risk for complex disease and quantitative physiological measurements collected on large populations.

Methods

A total of 3075 quantitative lab tests were extracted from Vanderbilt University Medical Center's (VUMC) EHR system and cleaned for population-level analysis according to our QualityLab protocol. Lab values extracted from BioVU were compared with previous population studies using heritability and genetic correlation analyses. We then tested the hypothesis

SUBMITTER: Dennis JK 

PROVIDER: S-EPMC7807864 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature