Bugs and drugs: a systems biology approach to characterising the effect of moxidectin on the horse's faecal microbiome.

ABSTRACT:

Background

Anthelmintic treatment is a risk factor for intestinal disease in the horse, known as colic. However the mechanisms involved in the onset of disease post anthelmintic treatment are unknown. The interaction between anthelmintic drugs and the gut microbiota may be associated with this observed increase in risk of colic. Little is known about the interaction between gut microbiota and anthelmintics and how treatment may alter microbiome function. The objectives of this study were: To characterise (1) faecal microbiota, (2) feed fermentation kinetics in vitro and (3) metabolic profiles following moxidectin administration to horses with very low (0 epg) adult strongyle burdens.

Hypothesis

Moxidectin will not alter (1) faecal microbiota, (2) feed fermentation in vitro,

SUBMITTER: Daniels SP 

PROVIDER: S-EPMC7807906 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature