Effect of apoA-I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins.

ABSTRACT: Biomimetic high-density lipoproteins (b-HDL) have in the past two decades been applied for various drug delivery applications. As b-HDL inherently have relatively long circulation half-life and high tumor accumulation, this has inspired researchers to use b-HDL to selectively deliver drugs to tumors. PEGylation of the b-HDL has been pursued to increase the circulation half-life and therapeutic efficacy even further. The b-HDL consist of lipids stabilized by a protein/peptide scaffold, and while PEGylation of the scaffold has been shown to greatly increase the circulation half-life of the scaffold, the effect of PEGylation of the lipids is much less significant. Still, it remains to be evaluated how the biological fate, including cellular uptake, biodistribution, and circulation half-life,

SUBMITTER: Pedersbæk D 

PROVIDER: S-EPMC7808163 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature