PH-Dependent peptide bond formation by the selective coupling of α-amino acids in water.

ABSTRACT: A novel mechanism enabling selective peptide elongation by coupling α-amino acids over other potentially competing prebiotic amines under acidic aqueous condition is suggested. It proceeds via the generation of a carboxylic acid anhydride intermediate with subsequent intramolecular formation of the amide bond.

SUBMITTER: Wu LF 

PROVIDER: S-EPMC7808311 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature