Physical constraints in polymer modeling of chromatin associations with the nuclear periphery at kilobase scale.

ABSTRACT: Interactions of chromatin with the nuclear lamina imposes a radial genome distribution important for nuclear functions. How physical properties of chromatin affect these interactions is unclear. We used polymer simulations to model how physical parameters of chromatin affect its interaction with the lamina. Impact of polymer stiffness is greater than stretching on its configurations at the lamina; these are manifested as trains describing extended interactions, and loops describing desorbed regions . Conferring an attraction potential leads to persistent interaction and adsorption-desorption regimes manifested by fluctuations between trains and loops. These are modulated by polymer stiffness and stretching, with a dominant impact of stiffness on resulting structural configurations. We infe

SUBMITTER: Brunet A 

PROVIDER: S-EPMC7808377 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature