Ontology highlight
ABSTRACT:
SUBMITTER: Brunet A
PROVIDER: S-EPMC7808377 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Brunet Annaël A Destainville Nicolas N Collas Philippe P
Nucleus (Austin, Tex.) 20211201 1
Interactions of chromatin with the nuclear lamina imposes a radial genome distribution important for nuclear functions. How physical properties of chromatin affect these interactions is unclear. We used polymer simulations to model how physical parameters of chromatin affect its interaction with the lamina. Impact of polymer stiffness is greater than stretching on its configurations at the lamina; these are manifested as trains describing extended interactions, and loops describing desorbed regi ...[more]