Dataset Information

Examination of individual and multiple comorbid conditions and health-related quality of life in older cancer survivors.

ABSTRACT:

Purpose

Older cancer survivors (≥ 65 years at diagnosis) are at high-risk for multimorbidity (2 + comorbid conditions). However, few studies have utilized a generalizable sample of older cancer survivors to understand how individual comorbid conditions, as opposed to total comorbidity burden, are associated with health-related quality of life (HRQOL). We examined associations between HRQOL outcomes (pain, fatigue, physical function), individual comorbidities (cardiovascular disease [CVD], lung disease, diabetes, arthritis) and total comorbidity (cancer-only, cancer + 1 condition, cancer + 2 or more conditions).

Methods

Utilizing a population-based sample of 2019 older cancer survivors, we tested associations between comorbid conditions and the HRQOL outcomes using generalized linear models. HRQOL domains were assessed using Patient-Reported Outcome Measurement Information System^® (PROMIS^®) measures. Comorbidity was assessed via self-report.

Results

Cancer survivors with lung disease reported significantly worse physical functioning (β = - 4.96, p < 0.001), survivors with arthritis reported significantly higher pain (β = 4.37, p < 0.001), and survivors with CVD reported significantly higher fatigue (β = 3.45, p < 0.001) compared to survivors without each condition. Having cancer + 1 condition was not as strongly associated with all outcomes as when individual conditions were tested (e.g. pain: β = 3.09, p < 0.001). Having 2+ comorbidities had a stronger association with all outcomes (e.g. physical function: β = - 7.51, p < 0.001) than examining conditions individually.

Conclusions

Knowing the specific comorbid condition profile of an older cancer survivor provides insight into specific HRQOL outcomes that may be impaired in cancer survivorship, but understanding total comorbidity burden, regardless of the specific conditions, sheds light on survivors at-risk for multiple impairments in HRQOL. This information, taken together, can inform risk-stratified survivorship care.

SUBMITTER: Siembida EJ

PROVIDER: S-EPMC7808400 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

Examination of individual and multiple comorbid conditions and health-related quality of life in older cancer survivors.

Siembida Elizabeth J EJ Smith Ashley Wilder AW Potosky Arnold L AL Graves Kristi D KD Jensen Roxanne E RE

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20210114 4

<h4>Purpose</h4>Older cancer survivors (≥ 65 years at diagnosis) are at high-risk for multimorbidity (2 + comorbid conditions). However, few studies have utilized a generalizable sample of older cancer survivors to understand how individual comorbid conditions, as opposed to total comorbidity burden, are associated with health-related quality of life (HRQOL). We examined associations between HRQOL outcomes (pain, fatigue, physical function), individual comorbidities (cardiovascular disease [CVD] ...[more]

PMID: 33447956

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Dataset Information

Examination of individual and multiple comorbid conditions and health-related quality of life in older cancer survivors.

Purpose

Methods

Results

Conclusions

Publications

Examination of individual and multiple comorbid conditions and health-related quality of life in older cancer survivors.

Similar Datasets

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