Congenital abnormalities associated with Zika virus infection-Dengue as potential co-factor? A systematic review.

ABSTRACT: Zika virus (ZIKV) emerged in Brazil during 2013-2014 causing an epidemic of previously unknown congenital abnormalities. The frequency of severe congenital abnormalities after maternal ZIKV infection revealed an unexplained geographic variability, especially between the Northeast and the rest of Brazil. Several reasons for this variability have been discussed. Prior immunity against Dengue virus (DENV) affecting ZIKV seems to be the most likely explanation. Here we summarise the current evidence regarding this prominent co-factor to potentially explain the geographic variability. This systematic review followed the PRISMA guidelines. The search was conducted up to May 15th, 2020, focussing on immunological interactions from Zika virus with previous Dengue virus infections as potential tera

SUBMITTER: Petzold S 

PROVIDER: S-EPMC7808571 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature