Viral load care of HIV-1 infected children and adolescents: A longitudinal study in rural Zimbabwe.

ABSTRACT:

Introduction

Maintaining virologic suppression of children and adolescents on ART in rural communities in sub-Saharan Africa is challenging. We explored switching drug regimens to protease inhibitor (PI) based treatment and reducing nevirapine and zidovudine use in a differentiated community service delivery model in rural Zimbabwe.

Methods

From 2016 through 2018, we followed 306 children and adolescents on ART in Hurungwe, Zimbabwe at Chidamoyo Christian Hospital, which provides compact ART regimens at 8 dispersed rural community outreach sites. Viral load testing was performed (2016) by Roche and at follow-up (2018) by a point of care viral load assay. Virologic failure was defined as viral load ≥1,000 copies/ml. A logistic regression model which included demographics, tre

SUBMITTER: Mapangisana T 

PROVIDER: S-EPMC7808638 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature