Molecular Biological Features of Nottingham Histological Grade 3 Breast Cancers.

ABSTRACT:

Introduction

Cancer biology dominates the behavior and prognosis of a tumor. Although Nottingham histological grade is a subjective pathological determination, it has been accepted as a surrogate model for cancer biology. As such, histologic grade was incorporated into the latest 8th edition of the American Joint Committee on Cancer breast cancer staging system. In this study, we hypothesized that grade 3 breast cancers demonstrate aggressive molecular biological profiles, reflecting worse biology and possible underlying immunogenicity.

Methods

Transcriptomic and clinical data were obtained from the Molecular Taxonomy of Breast Cancer International Consortium, and the findings were validated by The Cancer Genome Atlas breast cancer cohort and GSE25066.

Results

Overall

SUBMITTER: Takahashi H 

PROVIDER: S-EPMC7808708 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature