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Phasic Activation of Dorsal Raphe Serotonergic Neurons Increases Pupil Size.

ABSTRACT: Transient variations in pupil size (PS) under constant luminance are coupled to rapid changes in arousal state,^1-3 which have been interpreted as vigilance,⁴ salience,⁵ or a surprise signal.^6-8 Neural control of such fluctuations presumably involves multiple brain regions⁵^,^9-11 and neuromodulatory systems,³^,¹²^,¹³ but it is often associated with phasic activity of the noradrenergic system.⁹^,¹²^,¹⁴^,¹⁵ Serotonin (5-HT), a neuromodulator also implicated in aspects of arousal¹⁶ such as sleep-wake transitions,¹⁷ motivational state regulation,¹⁸ and signaling

SUBMITTER: Cazettes F

PROVIDER: S-EPMC7808753 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Phasic Activation of Dorsal Raphe Serotonergic Neurons Increases Pupil Size.

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