Determination of lumefantrine as an effective drug against Toxoplasma gondii infection - in vitro and in vivo study.

ABSTRACT: Toxoplasma gondii is an obligate intracellular protozoan parasite, which can infect almost all warm-blooded animals, including humans, leading to toxoplasmosis. Currently, the effective treatment for human toxoplasmosis is the combination of sulphadiazine and pyrimethamine. However, both drugs have serious side-effects and toxicity in the host. Therefore, there is an urgent need for the discovery of new anti-T. gondii drugs with high potency and less or no side-effects. Our findings suggest that lumefantrine exerts activity against T. gondii by inhibiting its proliferation in Vero cells in vitro without being toxic to Vero cells (P ≤ 0.01). Lumefantrine prolonged mice infected with T. gondii from death for 3 days at the concentration of 50 μg L-1 than negative control (phosphate-buffered s

SUBMITTER: Wang D 

PROVIDER: S-EPMC7808861 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature