Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19.

ABSTRACT: The severity of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), greatly varies from patient to patient. In the present study, we explored and compared mutation profiles of SARS-CoV-2 isolated from mildly affected and severely affected COVID-19 patients in order to explore any relationship between mutation profile and disease severity. Genomic sequences of SARS-CoV-2 were downloaded from Global Initiative on Sharing Avian Influenza Data (GISAID) database. With the help of Genome Detective Coronavirus Typing Tool, genomic sequences were aligned with the Wuhan seafood market pneumonia virus reference sequence and all the mutations were identified. Distribution of mutant variants was then compared between mildly and severely affe

SUBMITTER: Biswas SK 

PROVIDER: S-EPMC7808873 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature