Newborn telomere length predicts later life telomere length: Tracking telomere length from birth to child- and adulthood.

ABSTRACT:

Background

Telomere length (TL) is considered a biological marker of aging and may indicate age-related disease susceptibility. Adults and children show a fixed ranking and tracking of TL over time. However, the contribution of an individual's initial birth TL to their later life TL is unknown. We evaluated change and tracking of TL from birth to child- and adulthood.

Methods

Telomere length at birth was measured using qPCR in two independent prospective birth cohorts. After a median follow-up period of 4 years in ENVIRONAGE (n = 273) we assessed leukocyte telomere length (LTL) and after 23 years in EFPTS (n = 164) buccal TL was assessed. Correlations and multivariable regression models were applied to study telomere tracking and determinants of TL change from birth onwards.

SUBMITTER: Martens DS 

PROVIDER: S-EPMC7808927 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature