Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis.

ABSTRACT:

Objective

Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a key feature of adipose dysfunction and inflammation. However, very little is known about the direct effects of impaired cell-matrix interaction in adipocyte function and insulin sensitivity. The objective of this study was to determine whether integrin activity can regulate insulin sensitivity in adipocytes and thereby systemic metabolism.

Methods

We characterized integrin activity in adipose tissue and its consequences on whole-body metabolism using adipose-selective deletion of β1 integrin (Itgb1^adipo-cre) and Kindlin-2 (Kind2^adipo-cre) in mice.

Results

We demonstrate that integrin signaling regulates white adipocyt

SUBMITTER: Ruiz-Ojeda FJ 

PROVIDER: S-EPMC7808956 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature