NT-PGC-1α deficiency attenuates high-fat diet-induced obesity by modulating food intake, fecal fat excretion and intestinal fat absorption.

ABSTRACT: Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α regulate metabolic adaptation by modulating many gene programs. Selective ablation of PGC-1α attenuates diet-induced obesity through enhancing fatty acid oxidation and thermogenesis by upregulation of NT-PGC-1α in brown adipose tissue (BAT). Recently, we have shown that selective ablation of NT-PGC-1α reduces fatty acid oxidation in BAT. Thus, the objective of this study was to test our hypothesis that NT-PGC-1α^-/- mice would be more prone to diet-induced obesity. Male and female NT-PGC-1α^+/+ (WT) and NT-PGC-1α^-/- mice were fed a regular chow or 60% high-fat (HF) diet for 16 weeks. Contrary to our expectations, both male and female NT-PGC-1α^-/- mice fed HFD were protected from di

SUBMITTER: Kim J 

PROVIDER: S-EPMC7809341 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature